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Effect of MEBO Wound and Ulcer Dressing on the Wound Caused by Laser Surgery on Naevus Flammeus Site
Add Time2011/3/11 9:21:30
HAN Sheng, ZHU Hao, WANG Xiao, et al.
Department of Burns & Plastic Surgery of Hebei Peoples Hospital, Shijiazhuang City, Hebei Province, 050051, China
AbstractObjective: To observe the effect of MEBO Wound and Ulcer Dressing on relieving pains and shortening the wound healing time for the wound caused by laser surgery on Naevus Flammeus site. Method: The 42 cases of Naevus Flammeus patients post laser surgery were randomly divided into test group and control group. Test group was dressed with MEBO Wound and Ulcer Dressing and control group was applied with ciprofloxacin gel. The pain degree and wound healing time were compared between the two groups. Results: The pain degree in test group was notably lower than that in control group (P<0.01) and the duration of pain and wound healing time were shorter obviously than that in control group (P<0.01) Conclusion: MEBO Wound and Ulcer Dressing has remarkable efficacy in relieving pains and promoting wound healing of the wound caused by laser surgery.
Key wordsMEBO Wound and Ulcer Dressing; Naevus Flammeus; Laser surgery; Wound; Treatment
With the development of laser technology in recent years with its selective photothermy character, laser surgery has become the top choice to treat naevus flammeus. However, there are post surgery complications occurring like pains, flare, errhysis, blister, scab similar to I to superficial II degree burn wound. The conventional typical method like topical use of ciprofloxasin has disadvantages including delayed healing time, heavy pains and discoloration at the late stage. From November of 2006, MEBO Wound and Ulcer Dressing was used and compared with ciprofloxasin gel for post laser surgery wound treatment and satisfactory results were obtained as reported below:
I Data and methods
1 Clinical data: there are 42 cases including 18 males and 24 females with age ranging from 9 to 48 years, course of disease from 8 to 46 years and wound size from 4cm246cm2. All the patients were divided by random digits table into test group and control group, without significant difference in the age, gender, wound size, depth or laser energy. MEBO Wound and Ulcer Dressing was topically used on post surgery wounds of test group, and ciprofloxasin gel topically used on wounds of the control group.
2 Methods:
(1)Laser therapy: Outpatients were treated with Venus Plastic Laser Machine (COHERENT INC.), selecting green light with 532nm wavelength and frequency multiplication based on the depth of naevus flammeus. Before surgery, take photos of the wound and then apply 5% EMLA cream topically and cover the wound with scotch tape for one hour. Treatment was performed using built-in airtight cool recycling machine with 10ms30ms of pulse-width, 2mm4mm of spot, 7J18J/cm2 of energy density and 2Hz2.4Hz of repeat frequency.
(2)Post-surgery management: In test group, use ice bag for cool compress of the wound post surgery for one hour, and then clean the wound with sterile saline cotton bud. Choose MEBO Wound and Ulcer Dressing in proper specification to dress the wound and change dressing once a day till healing. Wounds in control group after cool compress were treated with ciprofloxacin gel topically 3 times a day till scab shedding. Alcohol or aspirin were forbidden throughout the course of treatment post surgery.
(3) Assessment of therapeutic results
      Pain grade and duration: Pain grade of test and control group was assessed by visual analogue scales 30min after wound management. Method: Use the 10cm length of nomadic scale having ten graduations on one side ranging from 0 value on the left to 10 value on the right, 0 indicating painlessness and 10 intolerable pain. Face the graduations towards the patient during the measurement and let the patient mark the right position indicating the felt pain grade as the value for assessment. The duration of pain was recorded by the patient and told the observer the next day. The duration of pain was observed within 24 hours post surgery.
Wound healing time: It was regarded as healing when scab shedding completely from the wound and the base finished epithelialization. Observe the wound once per day and record wound status including flare, exudation and scab.
3 Statistical method: Calculate P value with t test, significance criteria being =0.05

II Results

Table 1 Comparison of wound pain grade and duration between two groups



wound pain gradescore

wound pain duration h

Test group




Control group




There was very significant difference between the two groups, P<0.01.

Table 2 Comparison of wound healing time between two groups



Wound healing timed

Test group



Control group



There was very significant difference between the two groups, P<0.01

III Discussion

Multiple-frequency NdYag and 532nm wavelength laser has been used as one of the top choices in treating naevus flammeus and other superficial vascular diseases[1] currently. However, there are usually consequent symptoms such as pain, flare, errhysis, blistering and scarring of the wound in various degrees caused by the high local energy of the laser though local anesthetic and cool compression are performed before and after laser surgery respectively. The analysis is made about the solutions on the rising concerns during the wound treatment as followed.

1 Developing trend of wound treating environment: In recent years, there are studies by scholars on the environmental effect on the wound healing, which show that liquid environment is favorable for wound healing and closed liquid environment is more beneficial on wound healing compared with dry environment [2, 3]. As US FDA emphasized in its newly promulgated guideline for medical products (topical drugs and dressings) for wound use in August of 2000, the standard wound management method is to maintain the moist environment of the wound bed. Undoubtedly, that proposal is significant to promote the development of enclosed moist dressing into a promising mainstream wound dressing. Compared with conventional dressings, the enclosed dressing can maintain the moist environment and avoid adherence to the wound, accelerate wound epithelialization and granulation tissue formation as well as decomposition of fibrin and necrotic tissues, and inhibit the multiplication and diffusion of bacteria, consequently shortening the wound healing time and decreasing infection rate.  

With the emerging of various new enclosed medical dressings in the market, the functions of those products are getting more and more refined, and smart is the trend for enclosed dressing development based on the conventional medical theory. MEBO Wound and Ulcer Dressing is a physiological moist dressing composed of technology and ingredients catered for in situ skin regenerative restoration as well as sesame-oil-and-beeswax-immersed non-woven fabrics and auto-adhesive patch, developed by Chinese scholars in recent years based on the theory of Regenerative Medicine founded by Prof. Xu Rongxiang. Such dressing characterized by its special net-in-net structure can isolate the wound from damages by the air and secondary contaminations on one hand, and sesame oil contained in the dressing can alleviate local inflammatory cell exudation and infiltrate and reduce toxins production in order to reduce wound injuries on the other hand. When using MEBO dressing to dress the wound, there will be a layer of transparent fabric isolation-membrane formed between the wound surface and the dressing. That membrane is lipoprotein complex composed of ingredients in the dressing reacted with lipids and plasma proteins on the wound surface, which has functions of establishing and maintaining the physiological moist environment of the wound, resembling characters and functions of the semi-permeable membrane and also invigorating the proliferation of epithelial cells and fibroblast. In addition, some researchers used Moist Exposed Burn Ointment (MEBO) to treat wound after laser surgery on naevus flammeus site and obtained satisfactory results[4,5]. Therefore, we applied MEBO dressing in clinic which containing MEBO ointments ingredients in its uniquely designed MEBO dressing and in combination with characters of the wound after laser surgery on naevus flammeus site, and also attained notable results.

  Author Introduction

Han Sheng (1968~), male, born in Shijiazhuang City, Hebei Province, graduated from Chengde Medical College in 1991, associate Professor and associate chief physician on burn and plastic surgery.

Zhu Hao (1965~), female, born in Chengde City, Hebei Province, graduated from Nursing Department of Hebei Medical University in 1986, supervisor nurse.

Wang Xiao (1980~), female, born in Hengshui City, Hebei Province, graduated from Postgraduate Department of Hebei Medical University in 2006, physician on plastic and reconstructive surgery.

(Received date: Jan. 21st, 2008)

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