Built upon MEBO’s innovative technologies and products for the regeneration of wounded skin that leads to restoration of normal skin structure and function, MEBO has developed a series of products that are formulated for oral delivery and can be taken conveniently in the form of soft gel capsules by users to maintain the integrity of or to repair/regenerate the mucosal tissue without scar formation. Similar to the process of regeneration of the epithelium of the skin, repair or regeneration of damaged or eroded epithelium on the mucosal lining can be achieved by activating and sustaining intrinsic regenerative potential of the body and cultivating stem cells of the body in situ, i.e., right at the site of ulcerative lesion. 

As shown below, the mucosal tissues of those who suffered from various GI disorders (such as gastric ulcer, duodenal ulcer and erosive gastritis due to the side effects of chemotherapy and radiation) can be regenerated after a month of taking the MEBO regenerative nutrients.  The newly regenerated mucosa is scarless. 

As shown below in Figures 7.3.1 and 7.3.2, healthy adult humans, even if having degenerated/atrophic shortened villi on the GI lining due to aging, can still benefit from the regenerative power of the MEBO nutrients which promote re-growth of lush, longer villi (which are associated with a more youthful human body).  By using the MEBO nutrients to regenerate the GI lining without scar formation, the GI system is revitalized functionally to allow better absorption of nutrients to the body, which, in turn, leads to nourishment of the body systematically.

Normal human living intestine was obtained from surgical operations, and enzymatically digested so as to obtain dispersed single cells from the intestine samples.  The suspended intestinal cells were cultured in MEM medium and divided into two groups: test group and control group.  The MEBO regenerative nutrients were added to the cultures in the test group, while the control group did not receive any supplement.  Every 3 days the old growth medium was discarded and fresh growth medium same as the first round was added to the cultures in the respective groups.

After 55 days of culture, in the treatment group the cells had grown into groups of cells appearing in various forms, including proliferation and differentiation of the cells isolated from human intestine samples.  As shown in Figure 7.4.1.1a-c, in some areas, some of cells formed clusters that appeared to look like pieces of tissue.  Surprisingly, it was observed that in some areas, tissue pieces resembling a fully assembled villus structure appeared in the culture Figure 7.4.1.1d.  In comparison, most cells in the control group had died by Day 55. 

To further test the ability of the MEBO regenerative nutrients to facilitate cloning of physiologically correct tissue in vitro, experiments were conducted on explants of mouse intestine.  Explants of mouse intestine were obtained and a few villi on the explants were excised and cultured in normal cell culture medium.  The cultured explants were divided into two groups: test group and control group.  The MEBO regenerative nutrients were added to the cultures in the test group, while the control group did not receive any supplement. 

As shown in the panels in Figure7.4.4.1a-d, in the treatment group the explants not only survived but also grew new villi from the wound where the original villi had been removed.  By day 6, nascent structure of villus started to appear on the wound, and by day 8 regeneration of multiple new villi with the same physiological structure as the original ones was complete.  By contrast, explants in the control group gradually disintegrated and died in the culture (Figure7.4.4.2a-d).