GLOSSARY
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Clinical practice [Biochemical reactions]
It refers to six biochemical reactions, including hydrolysis, enzymolysis, rancidity, saponification, lipofication and esterification by which necrotic tissue on wound bed will be liquefied and be easier to be discharged without secondary damage to viable tissue.
[Burns]
Burns are classified according to the depth of the burn. In partial-thickness burns some part of the stratum basale remains viable, and regeneration of the epidermis occurs from within the burn area as well as from the edges of the burn. Partial-thickness burns are divided into first-and second-degree burns.
First-degree burns involves only the epidermis and are red and painful, and slight edema, or swelling, can be present. They can be caused by sunburn or brief exposure to hot or cold objects, and they heal without scarring in about a week.
Second-degree burns damage the epidermis and the dermis. If there is minimal dermal damage, symptoms include redness, pain, edema, and blisters. Healing takes about 2 weeks, and there is no scarring. If the burn goes deep into the dermis, however, the wound appears red, tan, or white; can take several months to heal; and might scar. In all second-degree burns, the epidermis regenerates from epithelial tissue in hair follicles and sweat glands, as well as from the edges of the wound.
In full-thickness, or third-degree, burns the epidermis and the dermis are completely destroyed, and recovery occurs from the edges of the burn wound. Third-degree burns often are surrounded by areas of first- and second-degree burns. Although the first- and second-degree burn areas are painful, the region of third- degree burn is usually painless because sensory receptors in the epidermis and dermis have been destroyed. The wound with third-degree burns appear white, tan, brown, black, or deep cherry red.
Deep partial-thickness and full-thickness burns take a long time to heal, and they form scar tissue with disfiguring and debilitating wound contracture. To prevent these complications and to speed healing, skin grafts are often performed. In a split skin graft the epidermis and part of the dermis are removed from another part of the body and placed over the burn. Interstitial fluid from the burn nourishes the graft until blood vessels grow into the graft and supply it with nourishment. Meanwhile, the donor tissue produces new epidermis from epithelial tissue in the hair follicles and sweat glands in the same manner as in superficial second-degree burns.
[BRT]
Is the abbreviation of Burns Regenerative Therapy, established by Professor Rongxiang Xu, is an innovative therapeutic system completely different from the conventional burn management, both in concept and in practice. This new approach is aimed at treating damaged tissue organs in skin by potentiating and stimulating Potential Regenerative Cells and Stem Cells in situ and thereby directly repairing and regenerating tissues of the skin without transplantation.
[CBAIM]
The Chinese Burn Association of the Integration of Traditional and Western Medicine (CBAIM) was officially founded on December 28,1996; it is an independent, not-for-profit organization dedicated to stimulating and supporting burn-related research, education, care, rehabilitation, and prevention. Especially to worldwide spread and popularize the Burns Regenerative Therapy, which is an innovation in burn care field, proposed by Prof. Xu Rongxiang. To advance these goals, the CBAIM sets up a national medical network with many burn centers and hospitals to provide first aid service and medical supervision, sponsors a variety of educational programs, fellowships, research, teaching and publications.
[Recovery stars]
From 1998, the CBAIM appraise about 10 Burn Recovery Stars each year from numerous of depth burn patients, the total burn body surface area of them all exceeded 90% and they were successfully salvaged and cured with Burn Regenerative Therapy (BRT).
[Debridement]
Debridement is the medical removal of a patient's dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue. Removal may be surgical, mechanical, chemical, autolytic (self-digestion), and by maggot therapy, where certain species of live maggots selectively eat only necrotic tissue. Generally, partial viable tissue will be debrided to promise no necrotic tissue left.
[De-escalation of anti-microbial treatment]
It means the empirical application of high-efficient, low-toxicity and broad-spectrum antibiotics for the critical patients during the early stage to prevent the aggravation of patient’s condition as a result of infection.
[Diuretic mixture]
1% Procaine 50ml-100ml, Caffeine Sodium Benzoate 0.5g, aminophylline 0.25g, Vitamin C 1g-2g and 10%-25% Glucose Solution 500ml are mixed and given via i.v. in drip
[Exudate]
Any fluid that filters from the circulatory system into lesions or areas of inflammation.
[Escharectomy]
Also called eschar excision. To surgically remove the eschar on deep burn wound.
[Escharotomy]
An escharotomy is a surgical procedure used to treat full thickness (third-degree) circumferential burns. Since full thickness burns are characterized by tough, leathery eschar, an escharotomy is used primarily to combat compartment syndrome. Following a full thickness burn, as the underlying tissues are rehydrated, they become constricted due to the eschar's loss of elasticity, leading to impaired circulation distal to the wound.
[Fibrous isolation membrane]
MEBO has good compatibility with burn wound exudates and can form a fibrous isolation membrane in the course of wound necrotic tissue liquefaction. The membrane is composed of lipoids produced by the biochemical reactions of MEBO and lipoproteins complexes produced by exudates of plasma protein from wounds. The membrane tightly covers the wound surface, so that the neo regenerative stuff can attached to it and the wounds can be repaired in a regenerative way in physiologically moist environment.
[Gas gangrene]
Gas gangrene (also known as "Clostridial myonecrosis" and "Myonecrosis") is a bacterial infection that produces gas tissues in gangrene. It is a deadly form of gangrene usually caused by Clostridium perfringens bacteria. It is a medical emergency.
[Human body regenerative restoration science]
It is an innovative application system of life science on the regenerating life activity and principle of PRCs induction into stem cells, on the life activity and principle of the induced stem cells regenerative restoring tissues or organs in situ, and on the living requirements and essential life nutrients for cell regeneration so that to realizes the in situ regenerative restoration of organs with acquired defect, premature aging, mutation, premature apoptosis or severe organ tissue disorders by utilizing the regenerative potential and regenerative nutrients.
Potential regenerative cells (PRCs) are invigorated and cultured with regenerative nutrients and newly regenerated cells replenish the acquired cells defect in organs or tissues and replace cells with premature aging, mutation, premature apoptosis or severe organ tissue disorders in the organ tissues, realizing the effective medical treatment for diseases, disease prevention, suspension and restoration of premature aging, discontinuation or prevention of cellular mutation as well as health and longevity.
By that, the final goal can be achieved of the improved quality of human lives, the extended young state of the life circle, improved life level and reformed source energy for human life.
[Iatrogenic infection]
The term refers to the local or systemic infection caused by or resulting from medical treatment or advice.
[In situ regenerative restoration of tissues and organs]
Referring to a technical result that PRCs are induced into stem cells by regenerative nutrients combined with various techniques, and subsequently new tissues or organs are regenerated in situ to replace those losing structure and functions, so that they are completely integrated with the remaining original tissues or organs in structure and function.
[In situ regeneration]
The damaged or necrotic cells in organs regenerate into live tissue cells, tissues or organs in situ. This regeneration is not transplantation of cells, tissue or organs from in vitro.
[In vitro]
Literally, "in glass"; in a laboratory dish or test tube; an artificial environment.
[In situ]
A Latin phrase meaning "in the original location." In scientific experimentation, it refers to experiments conducted in the actual site of the phenomenon under study, in contrast to in vitro (outside the living body and in an artificial environment) and in vivo (in the living body of a plant or animal).
[Liquefaction & liquefactions]
MEBO Wound Ointment has net-like frame form. It's composed by grease and surrounding beeswax. There are abundant linoleic acids (belongs to non-saturation acid), which can be decomposed with sterol stuff, aldehyde oxide, keton oxide, lipid, adipoidand, etc. The necrotic tissue is softened and liquefied via six biochemical reactions (as the above). This process is called “liquefaction". The liquefied necrotic tissue is termed as 'liquefactions'.
[MEBT/MEBO (Moist Exposed Burn Therapy/Moist Exposed Burn Ointment)]
Is the abbreviation of Moist Exposed Burn Therapy and Moist Exposed Burn Ointment( a patented burn ointment)It was invented in the 1980s by Professor Rongxiang Xu. MEBO is a botanic drug consisting of multiple botanic components and animal nutritional ingredients cooperated with a unique patented sponge-like frame structure dosage form to treat various (depth/TBSA/cause) burns, wounds and ulcers in regeneration of skin organ.
[MEBO Gauze]
It refers to the man-made dressing that MEBO Wound Ointment is fully impregnated into the mesh of sterile dry gauze.
[Micro-skin implantation]
It refers to the clinical procedure that helps the closure of wound bed with growth of granulation tissue. Firstly, excise partial-thickness skin near wound bed in sterile procedure. Secondly, place the excised skin into sterile basin and use surgical scissor to sheer it into small pieces, the size is similar with the millet. And then implant the skin-pieces into granulation tissue and wrap the affected area up with MEBO Gauze and sterile dressing. The implanted skin pieces will be growing into skin islands in one-two weeks that will connect with each other and close the wound with less scarring.
[Moist exposed therapy]
Wound dressing with MEBO ointment only, without gauze or cotton dressing (The wound is treated under the cover and protection of MEBO ointment)
[Moist semi-exposed therapy]
Wound dressing with MEBO gauze (The wound is treated under the cover and protection of MEBO gauze).
[Moist bandage therapy]
Wound dressing with MEBO ointment, MEBO gauze and cotton dressing. (The wound is treated under the cover and protection of MEBO ointment, MEBO gauze and cotton dressing).
[Non-woven fabrics]
Nonwoven fabric is a fabric-like material made from long fibers, bonded together by chemical, mechanical, heat or solvent treatment. Non-woven materials are used in numerous applications, including: hygiene, medical, filters and geotextiles.
[Potential Regenerative Cells (PRCs)]
Referring to the type of tissue cells in human body that have the potential to proliferate and differentiate and subsequently develop into tissues or organs. Such cells share the similarity in the characteristic life circle with other common tissue cells which have no the above potential, but they are different from the common tissue cells in that can be induced into stem cells (indicating the concept of secondary life regenerative cells and long-term dormant cells).
[Skin-incision and tension-relieving technique]
This technique is to apply surgical instrument (specially designed) “Ploughing Saw Blade” or operating knife, rolling knife to incise wound surface, forming scratch about 1mm in spacing and depth to relieve the local tension caused by degenerative and necrotic epithelial tissue; help subdermal vascular plexus in circuit, initiate and activate PRCs of residual skin tissue and regenerate skin organ in situ.
[Stem cells]
'Stem cells' here in this book refer to the dynamic cells with the potency of proliferation and differentiation to form normal tissues or organs (or functional cells). Those which can proliferate and differentiate but not form the normal tissues or organs (or functional cells) should not be classified as stem cells, like cancer cells; the same case is with the common cells with injure repair ability which also have the proliferation and differentiation function but form the scar tissues instead of normal.
Stem cells can also be classified according to the origins or functions as follows: those derived from embryonic cells are called embryonic stem cells; those existing in the body as the state of stem cells are called adult stem cells; those transformed from tissue cells are called tissue (somatic) stem cells. Based on the functions, stem cells can be categorized into several types: totipotent, pluripotent or unipotent stem cells, like hemopoietic stem cells (HSC) with only the single function of hemopoiesis.
In a word, any cell called as a normal stem cell should share the common character of proliferation and differentiation to form normal tissues or organs (or functional cells). It is a serious concept mistake to term cells without the ability to form normal tissues or organs (or functional cells) as stem cells. For example, none of the virus assisted gene reprogrammed iPS cells has developed into the normal stem cell, not even mentioning the formed normal tissues or organs, thus the claim of iPS cells as ‘induced stem cells’ was a severe concept mistake. Instead, the inventor should name the iPS cells according to the actual cell character not by borrowing the existing term.
['Thinning' technique of necrotic tissue]
It refers to surgically excise 4/5 layer of necrotic tissue with Humby’s knife without bleeding and pain to extremely protect the viable tissue in obstructive layer of burn wound. The remaining 1/5 layer of necrotic tissue will be liquefied and discharged without secondary damage to the viable tissue by the action of MEBT/MEBO.
["Three No principles"]
"Three No principles" of MEBO application: no pain on wounds, no bleeding and no injury to living tissues.
["Three timely principles"]
"Three timely principles" is one important principle in the management of wounds; Timely removal of liquefied products, timely removal of necrotic tissue and timely application of the drug (MEBO).
["Three no accumulation"]
"Three no accumulation" is one important principle in the management of wounds; no accumulation of necrotic tissue, no accumulation of liquefied products and no accumulation of excessive drug (MEBO).
[The induction of somatic cells into stem cells]
Referring to the process by which somatic cells without the change of life properties are directly induced into stem cells that have the potential to proliferate and differentiate and subsequently develop into normal tissues or organs (or functional cells) with natural ingredients composed nutrients (or ingredients not changing the structure and characters of the cells).
Cell category [Life dominator]
It refers to life self extension and sustention domination after life entity formation. It has two ways, one being sustention decided by life genetic attributes, the other being acquired life sustention influenced by the nature.
[Daily life]
It refers to life self sustention activity after life entity formation.
[Regenerative nutrients]
It refers to the indispensible nutrients for invigorating and nourishing regenerative cell life.
[Vigor, Energy, Spirit and Strength]
It refers to human body's mental response, energy for activity, spiritual vitality and strength for muscular movement.
[Embryonic Stem Cells]
It indicates the primitive (undifferentiated) cells from the embryo that have the potential to become a wide variety of specialized cells.
[Adult stem cell]
An undifferentiated cell found in a differentiated tissue that can renew itself and (with certain limitations) differentiate to yield all the specialized cell types of the tissue from which it originated.
[Regenerative cells]
Referring to the collective name for all cells with regenerative potentiality
[The first life cells]
Referring to cells developing from embryo to different ultimate tissue cells
[The secondary life cells]
Referring to ultimate tissue cells with further regenerative potential to proliferate and differentiate again to develop into normal tissues and organs; such cells belong to the category of PRCs, and they are considered as the exceptional function of the first life cells since they have already completed the mission of ultimate differentiation and development
[In situ cells]
Referring to the naturally existing cells (original cells) in human tissues and organs instead of in vitro implanted cells
[In situ cell regeneration]
Referring to the transformation of the naturally existing cells in human tissues and organs to stem cells at their original to regenerate new cells
[Tissue/somatic stem cells]
Referring to the stem cells derived from tissue cells, as embryonic stem cells derived from embryonic cells
[In situ stem cells]
Referring to cells transformed from in situ tissue cells to function as stem cells in situ
[Dormant cells]
Referring to one type of PRCs which are produced in dissymmetrical mitosis during the coursed of human body development and remain in dormant status afterwards without further development
[Cell aging]
Referring to the course of cell fibrosis
[Aged cell]
Referring to the cells in fibrosis status
[Premature aging]
Referring to the aging coming in advanced stage before the supposed natural aging course by its life properties
[Cell mutation]
Referring to the transformation of cells to abnormal cells not going with the normal life
[Cell disorder]
Referring to the endogenous diseases resulted from cellular metabolism and structural disorder
[Cell regeneration]
Referring to the process of cell cloning to produce an identical new cell
[Cell regeneration relay]
Referring to the process of the cell-cloning produced identical new cell replacing another same functional cell
[Cell self-renewal]
Referring to the self-substitution of the same one cell without quantity change
[Totipotent stem cells]
Totipotency is the ability of a single cell to divide and produce all the differentiated cells in an organism, including extraembryonic tissues.[2] Totipotent cells include spores and zygotes.
[Pluripotent stem cells]
In cell biology, pluripotency refers to a stem cell that has the potential to differentiate into any of the three germ layers: endoderm (interior stomach lining, gastrointestinal tract, the lungs), mesoderm (muscle, bone, blood, urogenital), or ectoderm (epidermal tissues and nervous system).
[Unipotent stem cells]
In cell biology, a unipotent cell is one that has the capacity to develop/differentiate into only one type of tissue/cell type.
Tissue category:
[Tissue Organ Regenerative Nutritious Components]:
Cell nutritious components in vivo and in vitro, which could activate and maintain the process of cell proliferation and differentiation and finally form tissue organs.
[Tissue organ]
Referring to the functional tissue unit composed of more than one type of cells in human organs, which exert one or more than one life functions in human lives.
[Organ tissue]
Referring to tissues in the organ
[Cell connection]
Referring to the process of multiple newly regenerated cells linked together to form a tissue
[Tissue construction]
Referring to the process of the newly regenerated tissue units integrated together to form a larger tissue, tissue organ or organ
[In situ tissues]
Referring to the naturally existing tissues in the organs and tissues
[Physiological structure]
Referring to the structure identical to the original one of the organ or tissue in structure and life function
[Physiological healing]
Referring to the healing with the recovered physiological structure
[Tissue regenerative restoration in situ]
Referring to the in situ recovery of the tissue with defected or aging parts
[Organ regenerative restoration in situ]
Referring to the in situ recovery of the organ with defected or aging parts
[Tissue and organ regenerative restoration in situ]
Referring to the process of the in situ recovery of tissues and organs with defected or aging parts by in situ cell regenerated tissues and organs with the identical structure and function
[Suspension/discontinuity of the premature organ aging]
Referring to suspending the course of advanced aging
[Regenerative restoration of the premature aging]
Referring to the restoration of the tissues and organs in advanced aging back to the non-aging status by regenerative ways
Nutrients category: [Basic nutrients]
Referring to the discovered life-sustaining nutritional elements
[Total nutrition]
Referring to the discovered nutritions containing all the available nutrients
[Regenerative nutrition]
Referring to the nutrition essential for cells to display the regenerative function
[Regenerative substances/nutrients]
Referring to the nutritional ingredients required by regenerative cells for their life activities
[Regenerative nutrients compounds]
Referring to the various compositions of the ingredients of regenerative nutrients
[Regenerative restoration]
Referring to the structural and functional recovery of tissues and organs with in situ cell regeneration
[Regenerative restoration health preservation]
Referring to the measures to maintain the health of human body and sustain the normal status of tissues and organs by regenerative restoration technique
[Bio clock of human body]
Referring to the common life activity and principle of 80% cells of the human body
[Human bio clock diet]
Referring to the diet principle and amount of the food required by over 80% cells of the human body
[Regenerative total nutrient diet]
Referring to the total nutrient diet composed of regenerative nutritional ingredients catered for all types of cells going with human bio clock based on the need of human body regeneration
[Injury-free introduction of regenerative nutrients]
Referring to the technique causing no injury to the tissue to deliver regenerative nutrients into the human body
[Injured introduction of regenerative nutrients]
Referring to the tissue injury causing technique (eg. laser) to deliver regenerative nutrients into the human body
Application category:
[Regenerated life]
Referring to the life of a new living body generated by cell regeneration procedure
[Regenerated life expectancy]
Referring to the extended new lifespan after body regenerative restoration
[Regenerative medicine]
Referring to the medicine where the regenerative potential of the human body is used to realize human tissue and organ regenerative restoration in situ
[Regenerative repair]
Referring to repair the injured tissues or organs by regeneration procedure but not necessarily achieve the complete regenerative restoration
[Regenerative wound healing]
Referring to wound healing through the in situ regeneration of the residual tissues on the wound
[Wound regenerative restoration]
Referring to in situ regeneration of new tissues or organs with identical structure and function to the original ones on the wound
[Human body regenerative restoration in situ program]
Referring to the plan of in situ human body regenerative restoration for health preservation based on individual physical condition
Regenerative anti-cancer category
[Regenerative anti-cancer experiments]
Referring to the anti-cancer experiments performed by the method used in normal cell regeneration study
[Apoptosis type death of Cancer cells]
Cancer cell died with the process of cell apoptosis instead of the common cell necrosis which normally release toxins
[Cancer cell mutation]
The abnormally change of the structure and organ functions of cancer cell
["Three highs" diet]
Referring to high protein, high calories and high vegetable diet
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