However, the current standard care of wounded patients practiced in most part of the world has not met this requirement. In the treatment of extensive, large-area deep burn wounds, the goal is still only to increase the chance of survival. The typical procedure involves drying of the burned skin to enable the development of eschar over the burned tissue, which is then surgically excised to prepare to the wound bed for skin transplants in an effort to close the wound. To prevent infection, typically an antibacterial agent (such as silver sulphadiazine) is used in the wound dressing, which unfortunately can also impede regeneration of the nascent tissues on the wound. As a result, the wound may be closed but with distorted, incompletely regenerated skin that may lose partial or most of its normal structure and function, such as missing normal or growing dysfunctional appendages and tissues (hair follicles, glands, nerves and blood vessels).

Compared to healing of acute wounds (e.g., burns, scalds, bruise and surgical wounds), healing of chronic wounds represents an even grander challenge due to patients’ compromised immune system, poor blood circulation and other disease or physical conditions such as diabetes, paralysis or otherwise being long-term bedridden. The wounds are not only difficult to heal but also cause necrosis of healthy surrounding tissues, further exacerbating the condition and leading to amputation or death due to complications and infection. Similar to the treatment of acute wounds, the typical treatment of chronic wounds is still application of antiseptics and antimicrobials (such as hydrogen peroxide, dressings having cadexomer iodine and silver within) to the wounds, which may adversely affect growth of fresh granulation tissues and complete restoration of the structure and function of the tissues including the muscle, tendon, fat tissue, and skin.

Against this gloomy background, MEBO represents a beacon of hope for tissue and organ regeneration. By using a unique combination of botanicals (MEBO Wound Ointment) and tissue/organ regenerative techniques, millions of patients suffering from acute and chronic wounds in China, many countries in Asia and the Middle East have been successfully treated over the past two decades. Patients’ wounds are not only closed but also healed with restoration of the normal structure and function of the tissue and organ, thereby meeting the gold standard of regenerative medicine. The success of MEBO lies in its ability to

• Maintain wound in a physiological moist environment;
•Liquefy necrotic tissues that can be removed without damaging residual viable tissues;
• Promote wound healing by activating and sustaining intrinsic regenerative potential of the body and cultivating stem cells of the body in situ and in vivo;
• Improve wound microcirculation in the zone of stasis;
• Protect wounds from potential infection;
• Minimize pain and the use of analgesics;
• Restore physiological structure and function of the body; and
• Promote quality of healing by reducing scarring.

The following is a slide show demonstrating the process of wound healing and skin regeneration using MEBO Wound Ointment and its tissue/organ regenerative techniques:

SLIDE SHOW OF WOUND HEALING

For more clinical evidence, please visit the section of “Typical Clinical Case Profiles.”

For a summary of preclinical and clinical studies, please click on the following links:

• Guidance on Moist Exposed Burn Treatment (MEBT)
• Nonclinical Efficacy Pharmacology
• Clinical Efficacy Pharmacology
• Controlled Clinical Studies in Burn Injuries
• Clinical Applications on Wounds and Ulcers