In the field of limb regeneration it is generally held that vertebrates of lower species, particularly urodele amphibians (common called ¡°salamanders¡±), have an intrinsic capacity to regenerate a variety of body parts, including limbs, tail, jaw, and retina. In higher mammals, examples of complex tissue regeneration are less common but can be seen in the seasonal regrowth of deer antlers. For humans, there is description of distal fingertip regeneration in children, but not in fully developed adults if the amputation plane is proximal to the terminal interphalangeal joint. Some concluded that regenerative potential declines with the evolution of complexity. Gurtner et al. (2007) ¡°Progress and potential for regenerative medicine¡± Annu. Rev. Med. 58:299-312.
Application of MEBO¡¯s technology and products to the treatment of lost or severely damaged fingers or toes of adult humans can not only repair the wounds but also regenerate fingers or toes with normal structure and function, including bones, muscles, nerves, blood vessels, connective tissue, finger nails and skin.
As shown in the representative examples below, consistent results were obtained in more than 2,000 clinical cases. The general treatment procedure includes 1) cleansing the wounds without debridement, keeping as much viable tissue as possible; 2) avoiding sutures of the wound, allowing the wound to be exposed; 3) avoiding cutting away exposed bone residue and lacerated skin flaps; 4) applying MEBO ointment at 3-5 mm thickness to the wound and covering the wound with gauze; and 5) changing dressing every 24-48 hrs.
These results demonstrate that the regenerative potential of adult humans is much stronger than previously expected. Consistent with what was observed for the regeneration of the skin of patients with other types of acute and chronic wounds, the key to the clinical success lies in the establishment of an appropriate environment favoring regeneration and sufficient supply of nutrients to the cells on the wound to stimulate and sustain the regeneration of the body.
1. Regeneration of Adult Fingers after Loss of Distal Phalange
2. Regeneration of adult fingers after severe damages to middle and distal phalanges
3. Regeneration of Adult Fingers after Amputation Below the Terminal Interphalangeal joint