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 Burn Regeneration

1. In Situ Regeneration of Full-Thickness Skin 
2. Regeneration of Full-Thickness Skin of Pig Burn Wound Models Dynamic
3. Regeneration of Full- Thickness Skin in Humans 
    3.1 Regeneration of Skin in Patients with Deep Second- Degree Burns
    3.2 Regeneration of Skin in Patients with Full- Thickness Burns
    3.3 Regeneration of Full-Thickness Skin on Hand
    3.4 Regeneration Process of Full-Thickness Skin on Face and Neck
    3.5 Regeneration of Skin of Deep, Large-area Burn Wounds
    3.6 Treatment of Extremely Large-area Burn Wounds
4. Regeneration of Subcutaneous Tissue
    4.1 Regeneration of Soft Tissue
    4.2 Regeneration of Soft Tissue and Skin from Bone Marrow Cells

3.5 Regeneration of Skin of Deep, Large-area Burn Wounds

Extremely large (>40% TBSA) and deep (>2nd degree) burn wounds pose a major medical challenge due to massive loss of tissue and potential systemic complications.  To save life and heal the wounds, aggressive surgical approaches with early tangential excision and wound closure are usually taken.  Autografts from uninjured skin of the patient are taken to be used to cover the burn wounds, the wounds as a result of which further increase the TBSA affected.  When the patient’s skin donor sites are limited or the overall patient condition do not permit immediate grafting with autologous skin, human cadaver allograft skin (HCAS) and xenografts are used as temporary burn wound cover.  Serious problems, however, are associated with HCSA and xenografts, including limited supply, variable and occasionally poor quality, inconvenience of harvesting skin in the mortuary, and ultimate immune rejection. Cultured epithelial autografts have been developed for the treatment of extensively deep burns.  A major disadvantage of this approach is the delay in providing cultured keratinocyte sheets for practical clinical use, in addition to fragility and difficult handling of the grafts, an unpredictable “take” and extremely high costs. Widespread use of cultured autografts has been primarily hampered by poor long-term clinical results.  Even if the patient’s life is saved, severe disfigurement and disablement often result. 

Against this grim background, the innovative approach taken by Dr. Xu represents a major paradigm shift.  By using MEBT/MEBO, Dr. Xu and now a network of clinicians throughout China have successfully treated tens of thousands of patients with deep, extensive burn wounds.  The patients not only survived, but also thrived with minimum disfigurement and disablement. 

Shown below are a few examples of patients treated with MEBT/MEBO. 

Figure Partial-Thickness Burns Treated with MEBT/MEBO

Figure Treatment of Deep 3rd Degree Burns with MEBT/MEBO


Burn Regeneration
Trauma Wound Regeneration
Surgical Wound Regeneration
Limb Regeneration
Regeneration of Gastro- Intestinal Tract
Restoration of Aged Skin of Adult Humans
Systemic Regeneration of Aging High Mammals

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