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¡¡Burn Regeneration

1. In Situ Regeneration of Full-Thickness Skin 
2. Regeneration of Full-Thickness Skin of Pig Burn Wound Models Dynamic
3. Regeneration of Full- Thickness Skin in Humans 
    3.1 Regeneration of Skin in Patients with Deep Second- Degree Burns
    3.2 Regeneration of Skin in Patients with Full- Thickness Burns
    3.3 Regeneration of Full-Thickness Skin on Hand
    3.4 Regeneration Process of Full-Thickness Skin on Face and Neck
    3.5 Regeneration of Skin of Deep, Large-area Burn Wounds
    3.6 Treatment of Extremely Large-area Burn Wounds
4. Regeneration of Subcutaneous Tissue
    4.1 Regeneration of Soft Tissue
    4.2 Regeneration of Soft Tissue and Skin from Bone Marrow Cells

3.1 Regeneration of Skin in Patients with Deep Second- Degree Burns

To study the physiological healing process, histological examination was performed on tissue samples taken from deep second-degree burn patients under the treatment using MEBT/MEBO.  Xu ¡°Physiological Healing Procedure and Histological Observation on Deep Second-Degree Burns Treated with MEBO¡± Burns Regenerative Medicine and Therapy, 1st ed., Basel: Karger; 2004. p.106-111.

Six cases were enrolled throughout the study, 5 males and 1 female, aged from 21 to 36 years-old.  Total burns surface area varied from 12% to 45%, with an average of 24.33¡À12.37%.  All patients were admitted within 6 h post-burn.  After admission, patients received fluid resuscitation and antibacterial therapy on the basis of burn severity.  Burns wounds were applied with MEBO at a thickness of 1 mm, which was repeated every 4-6 h till wound was healed. 

As shown in Figure, the tissue at the wound site underwent dramatic patho-morphological changes during the treatment using MEBT/MEBO.  Under the conditions provided by MEBO wound ointment, pathological changes of the deep second-degree burn wounds can be divided into three stages: (1) denaturation and necrosis of injured tissue, (2) liquefaction and discharge of the denatured and necrotic tissues, and (3) restoration of physiological structure and function of the skin.  These stages may overlap.  As shown in Figure 1.2.1h, the newly regenerated skin has virtually an identical morphology and structure to that of non-injured skin.  No skin grafting was performed.  


Burn Regeneration
Trauma Wound Regeneration
Surgical Wound Regeneration
Limb Regeneration
Regeneration of Gastro- Intestinal Tract
Restoration of Aged Skin of Adult Humans
Systemic Regeneration of Aging High Mammals

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