Burn injury is a three-dimensional wound that causes massive tissue loss in the victim. Treatment of burn wounds involves a unique combination of modalities. In addition to topical wound care needs, the patient is at risk for numerous systemic complications associated with the absence of large amounts of epidermis and/or dermis. The goal is not only to save the patient¡¯s life but also to restore the structure and function of the body so as to prevent or minimize disfigurement and disablement.
In comparison, currently for deep partial thickness burns (extending into the reticular layer of the dermis) and full-thickness burns (extending through the dermis and into subcutaneous tissue), unless very small in size, the standard treatment modality is to use skin grafts to close the wounds. Prior to the skin grafting, the wound bed is usually prepared by treating with daily or twice-daily dressing changes with topical antimicrobial application to control the growth of microorganisms and prepare the wound for grafting. Honari (2004) Crit. Care Nurs. Clin. North. Am. 16:1. Bryant & Nix (2007) Acute & Chronic Wounds: Current Management Concepts, Chapter 18 by Jill Evans, 3rd Ed., Mosby, Inc.
Successful skin grafting could repair the wound through revascularization with sprouting and budding of vessels in both donor and recipient sites. Falabella & Kirsner (2005) Wound Healing, Chapter 41 ¡°Skin Grafting: Surgical Techniques¡± by Yamaguchi et al., Taylor & Francis Group, Boca Raton, FL. However, in the grafted epidermis and dermis, the function of the appendages of the skin such as hair follicles, nerves, sweat glands, and sebaceous glands is severely compromised, if not completely lost. Thus, although the patient¡¯s life is saved and wound closed, a significant loss of physiological functions of the skin results and, for patients with large area burns, decrease in morbidity is inevitable.
Dr. Xu¡¯s invention of the system of MEBT/MEBO brought a revolution to this field. Preclinical experiments on animal models and clinical application to the treatment of millions of patients in China and other countries demonstrate that under the regenerative conditions provided by using the MEBO technology (moist exposed burns therapy (MEBT) and the MEBO products (e.g., MEBO wound ointment and MEBO wound dressing), regeneration of full-thickness skin with restoration of physiological structure and function can be achieved.