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Effect of MEBO Wound and Ulcer Dressing on Skin Injury Wounds
Add Time£º2011/5/9 17:11:48
                                                                                                        CHEN Shou-wanª±
The Dept. of Burns and Plastic Surgery, the People¡¯s Hospital of Jianyang, Jianyang City, Sichuan Province, 641400, China
¡¾Abstract¡¿ Objective£º To observe the effect of MEBO Wound and Ulcer Dressing on skin traumatic wounds and surgical wounds. Method£º From May of 2007 to March of 2008, 72 cases of skin injury in-patients were treated with MEBO Wound and Ulcer Dressing. Results£º 71 cases were healed completely; one case of avulsion injury of skin with large area skin defect was healed with skin-grafting. Conclusion£º MEBO Wound and Ulcer Dressing is an optimal biologic dressing for accelerating wound restoration and healing, and for preventing or reducing scar formation. It¡¯s a safe and convenient topical medical dressing.
¡¾Key words¡¿ Wound and Ulcer Dressing, Traumatic wound, Healing
The principle of traumatic wound treatment is preventing infection, promoting wound healing and shortening healing time. EMBO Wound and Ulcer Dressing, produced by Shanghai MEBO Life & Technology Co., Ltd, is an artificial cell type medical active material consisting of purely natural substances with the utilization of liposome technology. From May of 2007 to March of 2008, 72 cases of skin traumatic in-patients were treated in our department with MEBO Wound and Ulcer Dressing and obtained satisfying results as is reported below.
I Clinical date and methods
1 General data: There were 72 cases in total, 47 male and 25 female, the age ranging from 4 to 69 years old with the average being 37¡À4.4 years old, all affected by multiple sites skin injuries including abrasion and contusion, laceration and avulsion caused by various reasons. Thereinto, there were 13 cases of head and face abrasion and contusion by car accidents, scalp avulsion 4 cases, chest or back abrasion and contusion 16 cases, four limbs abrasion, contusion and laceration 27 cases, the rest including skin hot-compression injury 4 cases, blast injury 3 cases, electrical injury 3 cases, chemical drug burn injury of four limbs 2 cases. With burn diagnosis criteria for analogy, superficial second degree injury 13 cases, deep second degree 26 cases, third degree 33 cases, 1%-12% TBSA; patients were admitted in hospital 1 hour to 3 days post injury, 4 cases getting infected; 67 cases had complicated injury.
2. Medication methods: All the patients were given anti-biotics by oral administration or i.v. drip to prevent or treat infection in combination with relevant symptomatic supporting treatment. Wound debridement and suture were performed on some patients, and then MEBO Wound and Ulcer Dressing was applied to cover the wound; for wounds not suitable for suture, after wound cleansing with 0.1% Benzalkonium Bromide and normal saline, tenderly dry the wound by sterile dry gauze, and MEBO dressing was directly applied to cover the wound. Change dressing after 24 hours for the first time, then conduct dressing change every 1 to 3 days depending on exudation condition until wound healing.
II Results
1. Effect: The 71 cases were completely healed without skin-grafting, the range of healing time being from 9 to 52 days. One case of avulsion injury with extensive skin defect healed by skin grafting over 14 days.
2. Toxic effect: All of 72 cases showed no local irritation symptoms and allergic reactions. There were no significant differences in the indexes of the liver, kidney and blood examination between before and after the drug application.
III Typical case
A 18-year-old female was admitted to hospital 2 hours post injury on the right lower limb rolled over by a truck. Admitting diagnosis: right lower limb seriously damaged and injured, hemorrhagic shock, open and comminuted fracture of the right tibia and fibula, comminuted fracture of the right tarsus, skin avulsion from right thigh to right haunch, pelvis multiple fracture, closed fracture of the left tibia and fibula. After admission£¬patients were immediate subjected to fluid resuscitation and blood transfusion to prevent shock, amputation on upper middle section of right shank in emergency department and replantation after cleaning of avulsion wounds followed by procedures of infection prevention and haemostasis. Patients were stable after treatment. Five days later, the necrotic replantated skin graft area reached 19cm*12cm which presented black dry scabs. After scab excision and haemostasis, cover the wound with MEBO dressing. On the third day of MEBO dressing application, there were liquefied necrotic tissues observed on the wound which were removed. On the fifth day, the wound looked freshly red with much less liquefied necrotic tissues and epidermis growing centripetally. After 10 days, most area of the wound healed, only small area of residual wound left, then continually change dressing till healing completely on the 23rd day post injury ( on 18th day of MEBO dressing application); the scar was not notable diagnosed after half a year follow up, the skin touched softly and local skin color was slightly deeper.
IV Discussion
   The key to wound treatment is protecting the residual epithelial and semi-viable tissues maximumly, promoting re-epithelialization, accelerating wound healing and preventing infection. MEBO Wound and Ulcer Dressing employs the water-embroidered non-woven fabric immersed with compound of sesame oil and beeswax in sponge-like dosage form, equipped with self-adhesive dressings pad, forming spatial frame structure with the complex configuration of ¡°net in net¡± structure. The mechanism of MEBO Wound and Ulcer Dressing: (1)It leaves a skin-like protective film on the wound which can reduce water evaporate and prevent the wound dried and deepened, hereby maintaining the physiological moist environment on the wound. Moreover, with the identical character and function of the semi-permeable membrane, the nutrients in the film can penetrate into deep layer of the wound, which not only plays a great role in promoting tissue cells regeneration, but also maintains the good permeability between the wound and exterior side of the membrane, improving the wound drainage and reducing risk of infection. (2)The physiological moist environment formed by MEBO dressing can effectively isolate the wound from the damage by the air and secondary exogenous contamination; meanwhile, sesame oil in the dressing can eliminate the local inflammatory cells exudation and infiltration, reduce toxins production, so as to relieve wound injury on the one hand, it can enhance the repair reaction and accelerate physiological wound healing by nutrients supplement to and activation of wound basal cells on the other. (3) MEBO dressing has the ¡°net-in-net¡± spatial structure, which, under the warming effect of local skin temperature, can separate and surround the necrotic tissues, and further initiate series of bio-chemical reactions to reduce the wound toxic substances and alleviate further damages to the wound.
   In conclusion, with the spatial frame structure and multiple bio-functions, MEBO Wound and Ulcer Dressing has the good analgesic effect, and can notably promote the healing of skin abrasion, contusion or avulsion wound, and thus is regarded as a safe, simple, convenient and high cost-effective topical medicine.
¡¾Author information¡¿
Chen Shou-wan (1972-), male, born in Jianyang City, Sichuan Province, graduated from Sichuan Luzhou Medical College in 1997, attending physician.
 (Received date: March 15th, 2008)

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