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¡¡Exploration of Fundamental Mechanisms of Adult Human Body Regeneration

1. Intrinsic regenerative potential of human body clinically validated by MEBO
2. Potentially Regenerative Cells (PRCs) in every tissue and organ of the body
3. The regeneration process recapitulates embryonic development process and mimics scar less wound regeneration of the fetus
4. Regenerative condition and environment
  4.1 Unique mode of debridement via liquefication of necrotic tissues to minimize injury to viable tissues
  4.2 Formation of a respiratory membrane on the wound
  4.3 A unique mode of controlling and preventing bacterial infection without using conventional antibacterial agents
  4.4 Creating and sustaining physiological moist environment to promote regeneration
  4.5 Clinical techniques for creating a regenerative local environment and condition

2. Potentially Regenerative Cells (PRCs) in every tissue and organ of the body

To regenerate the lost tissue or organ, multiple cell types must be produced to form the new tissue.  Where do these cells come from? 

In a fully developed adult human body adult stem cells constantly participate in normal homeostatic production of functional mature cells to maintain the structural and functional integrity.  Some in the field of stem cell research believe that adult stem cells reside in specific niches, such as epidermal stem cells in the bulge of a hair follicle, intestinal epithelial stem cells in the crypt at the base of the villus. Moore & Lemischka (2006) ¡°Stem cells and their niches¡± Science 311:1880-1885.  These stem cells, once destroyed, cannot be renewed.  

Through two decades of clinical and basic research, Dr. Xu and the team of scientists and clinicians have found that in response to the injury and under the conditions provided by using MEBO technology and products, ordinary somatic cells residing at the site of the wound can be induced or activated to behave like stem cells¡ªproliferate and differentiate orderly to provide multiple cell types to form new tissue with physiologically correct structure and function.  For example, in a full-thickness burn wound the so-called ¡°epidermal stem cell niches¡± in the bulge of hair follicle have been destroyed.  However, under the condition provided by MEBO, viable cells at the wound site are converted into epidermal stem cells so as to provide multiple cell types to form new dermis and epidermis with the correct architecture, as well as appendages, nervous and vascular networks of the skin with normal physiological function.  In addition, cultured under the condition provided by MEBO wound ointment, bone marrow cells from holes drilled on the bone at the wound site can be induced to differentiate orderly to produce multiple cell types that form new muscle, soft tissue and skin after burn injury that reaches the bone.

These results demonstrate that normal somatic cells in an adult body can be induced under specific conditions to behave like stem cells that proliferate and differentiate to produce various types of cells necessary to regenerate lost or damaged tissue. 

What is the nature and dynamics of wound regeneration process under the conditions provided by MEBO?


Core Science & Technology of MEBO
Exploration of Fundamental Mechanisms of Adult Human Body Regeneration
Eradication of Cancer Cells via Regeneration

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